- Adenocanthoma of the Stomach (A Case Report)
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Moon Ho Yang, Hyo Sook Park, Je G. Chi, Sang In Kim
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Korean J Cytopathol. 1969;3(2):59-63.
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- Adenoacanthoma of the stomach is a rare lesion of obscure origin. Approximately 43 anthenticated cases of primary adenoacanthoma of the stomach have been compiled since the first description made by Rolleston and Trevor in 1905. No special clinical features could be found which help to separate this unusual cell type from the usual adenocarcinoma.
Three theories concerning the origin of these unusual tumors are 1) squamous cell metaplasia. 2)heterotopic islands of squamous cells, and 3) tumor cells arising from the direct stimulation of undifferentiated multipotential cells in gastric mucosa.
A 37-year-old Korean male was admitted to Seoul National university Hospital because of rapid weight loss, vomiting and epigastric fullness of 3 months duration. Physical examination revealed a 47kg. weighing male, but showing essentially negative in that no abdominal masses were palpable, no lymphadenopathy was noted, and rectal examination was normal. The significant laboratory data included an upper gastrointestinal series which demonstrated an large filling defect in pyloric antrum along the greater curvature, and findings of pyloric stenosis.
The resected stomach contained a polypoid, focally ulcerating neoplastic mass measuring 4 cm. in maximum cross, which is infiltrating deep into muscularis. Serosa is partly involved grossly by neoplastic tissue, and several swollen lymph nudes were encountered along the greater curvature. Microscopic examination revealed infiltrating tumor masses that are comprised partly by differentiated, focally pearl forming squamous cell nests invading into external muscularis. In areas there are atypical glandular component, with evidence of mucin production.
- Congenital Endocardial Fibro-elastosis
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Je G. Chi, Geung Hwan Ahn, Sang Woo Kim, Sang Kook Lee
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Korean J Cytopathol. 1969;3(1):27-31.
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- An autopsy case of congenital endocardial fibro-elastosis in a newborn infant is described. The patient revealed acute fatal type of heart failure sixty-two days after the birth. Autopsy revealed grayish white mural thickening in the left ventricle, and this change also involved the mitral valvular structure showing irregular shortening and thickening. No evidence of other intra-cardiac malformation was present. Microscopically, the mural thickening consisted of exuberant proliferation of fibrous tissue as well as the elastic fibers. There were encountered scattered foci of small round cell infiltration in the thickened endocardium and subendocardial spaces.
- Congenital Sacro-Coccygeal Teratoma (Report of an Autopsy Case)
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Moon Ho Yang, Joong Hee Lee, Geung Hwan Ahn, Je G. Chi, Sang Kook Lee
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Korean J Cytopathol. 1969;3(1):33-37.
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- An autopsy case of a congenital sacrococcygeal teratoma in a dead born fetus of eight months gestation is reported. The fetus weighs 1.3 kg. and reveals a large protruding tumor mass in sacral region, measuring 14×10×10 cm. and weighing 400 gm. The tumor is completely covered with skin. The tumor masses are partly cystic and partly solid with variegated appearance on cut sections. Anteriorly the tumor is partly extending into spinal canal.
Microscopically the tumor is composed of various elements derived from trigerm layers. Most prominent elements are central nervous tissue with considerable amount of choroidal plexus. No evidence of malignancy is noted.
There are found no congenital anomalies except for the teratoma.
Brief review of literature is made.
- Adrenal Hemorrhage in a Newborn -An Autopsy Case Report-
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Kyu Sun Rhee, Je G. Chi
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Korean J Cytopathol. 1968;2(1):53-57.
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- A case of bilateral adrenal hemorrhage in a three-day-old boy who was born after a labor period of more than 19 hours to a pre-eclamptic woman has been presented. The body weight of the baby at autopsy was 4,720 grams.
The newborn developed a high fever, convulsion and dyspnea throughout the entire disease course.
Autopsy revealed a massive hemorrhage in the adrenal glands especially in the right, replacing the majority of the adrenal tissue proper. There also was a subdural hematoma in the right parietal region.
Birth trauma was assumed to be the most important contributing factor of the hemorrhage of the involved case. And it was emphasized that when the signs and symptoms of adrenal insufficiency appear in the infants born with difficulties, the adrenal hemorrhage should be considered first as the underlying cause.
- A Histopathologic Study on Lung Carcinoma
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Sang In Kim, Chong Soo Lee, Je G. Chi
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Korean J Cytopathol. 1967;1(1):17-22.
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- A Study was made on 104 cases (autopsy and biopsy) of primary lung carcinoma of Koreans obtained during a period of 10 years, 1957 to 1966, at the Department of Pathology, College of Medicine, Seoul National University.
The frequency ratio or relative incidence of lung cancer among all types of malignant tumors in the same period at this Department was 4.7 per cent in male and female together, thus ranking the sixth in frequency in male and the sixteenth in female.
The sex ratio of male and female was 5.5:1. The age distribution of lung cancer showed the highest frequency in the decade of 50-59 (34%) and also considerably high frequencies in the decades of 40-49 (27%) and 60-69 (26%). However, when related to the female only, 60-69 group was in the highest frequency. Ages of 104 cases ranged from 26 years to 79 years with the average of 48.2 years of age.
The one hundred and four cases of lung carcinoma were classified histologically into five types : squamous cell carcinoma 45 cases (43%), adenocarcinoma 29 cases (28%), oat cell carcinoma 17 cases (16%), undifferentiated carcinoma 12 cases (12%) and mixed type 1 case (0.9%).
It was emphasized that several findings of this study are in concord with the results of several other countries that are in definitely increasing tendency of lung cancer.
- A Histopathologic Study on Soft Tissue Tumors
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Chae Koo Lee, Sang Kook Lee, Je G. Chi
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Korean J Cytopathol. 1967;1(1):25-30.
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- An analysis of 336 cases of malignant and benign tumors of soft tissue, that were examined at the department of pathology, college of medicine, Seoul National University, during a period of 11 years from January 1955 to December 1965 was made.
Total 336 soft tissue tumors consisted of 79 malignant and 257 benign tumors, and occupied 10 per cent of total tumors that were examined at this department during the same period. And 79 malignant soft tissue tumors occupied 3.5% of total malignancies during the same period.
Seventy-nine malignant and 257 benign soft tissue tumors were histologically classified and tabulated. Among malignant tumors, fibrosarcoma, neurogenic sarcoma, fibroliposarcoma and leiomyosarcoma were especially prevalent, and among benign tumors hemangioma, lipoma, fibroma and neurofibroma were more commonly encountered.
Average ages of malignant and benign soft tissue tumors were 37 and 33 years respectively. Male was slightly preponderant than female in both malignant and benign tumors.
Site distributions of 336 soft tissue were also tabulated, and some tumors were selected and described in more detail.
- Pulmonary Hypoplasia Associated with Congenital Diaphragmatic Hernia
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Kyu Sun Rhee, Je G. Chi
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Korean J Cytopathol. 1967;1(1):43-47.
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- Two autopsy cases of pulmonary hypoplasia associated with congenital diaphragmatic hernia(Bochdalek foramen) have been presented.
The first case is a 12-hour-old new born infant, who was admitted for cyanosis and dyspnea. At operation, the left hemithorax was filled with loops of small intestine which had been herniated through a large defect in the left posterolateral portion of the diaphragm. The defect was properly repaired. However, the patient expired soon after operation showing persistent respiratory difficulty. At autopsy, both lungs were hypoplastic especially in the left, and no evidence of expansion was noted under the microscope.
The second case is a 3-day-old newborn infant who was admitted for cyanosis and general weakness. Soon after admission the patient expired. At autopsy, left lung weighed only 5 gm. and consisted of a rather stolid dark gray mass attached to the hilum. The spleen and loops of small intestine were found in the left hemithorax which had been herniated through a round defect in the left posterolateral portion of diaphragm.
Pathogenesis of pulmonary hypoplasia associated with diaphragmatic hernia of congenital origin is discussed and the related papers are briefly reviewed.
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